The online retailer and cloud computing provider said net profit more than doubled to $3.56bn (£2.76bn), beating analyst estimates.
Revenue growth slowed, however, in part because of weaker sales outside the US. Sales rose 17% to $59.7bn. It expects sales growth of 13% to 20% for the next three months.
And expenses growth slowed, albeit to a rate of 12.6%.
Sales for Amazon Web Services rose 41% to $7.7 billion in the three month period to the end of March.
“The benefits of cloud computing are clear for the user, and with profits up 59% this quarter, so are the advantages for Amazon,” said George Salmon, an analyst at stockbroker Hargreaves Lansdown.
“While the cost of building the data-driven infrastructure to support the cloud systems is vast, the fact it requires such deep pockets actually works in Amazon’s favour. It’s difficult to see how a new challenger can wrestle business away from the likes of Amazon, Google, and the latest member of the $1tn club, Microsoft.”
Microsoft has seen its stock market value top $1tn after reporting better-than-expected sales and profits.
The US software giant passed the mark briefly on Thursday, before its share price fell back.