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Smoking induces alcohol addiction

Dr. Oliver George, senior author and biologist at The Scripps Research Institute (TSRI), conducted a study using rat models and said that smoking can make people crave alcohol to the point where they become addicted to it. Oliver George said that it was a “vicious cycle” where nicotine made people crave alcohol to reward the brain and reduce

stress.The team first tested whether nicotine exposure could affect alcohol-drinking

behavior in rat models. They started with two groups of male rats where both groups

were given access to alcohol to establish the baseline of how much they would drink. The

rats drank a little bit, perhaps the equivalent of one or two beers for a human, but they

stopped before showing signs of drunkenness.After this, the researchers used alcohol

vapor to induce alcohol dependence in one group of rats. Dependence developed in about

two months. In subsequent tests where alcohol was freely available, these rats consumed

the equivalent of a six-pack of beer and had blood alcohol levels close to three times the

legal limit for humans.The second group of rats were exposed to both nicotine and

alcohol vapor. These rats developed alcohol dependence much faster-and they began

drinking the equivalent of a six-pack in just three weeks.The researchers then offered the

rats alcohol with the bitter compound quinine added to see if they could stop the rats from

drinking. Most rats decreased their alcohol consumption to avoid the bitter taste, but the

nicotine-exposed rats just kept drinking. This indicated that their behavior was

compulsive, much like alcoholism in humans.Using further neurological studies, George

and his colleagues tracked this compulsive behavior to the activation of “stress” and

“reward” pathways in the brain. The compulsive alcohol consumption and neurological

pathways seen in the new study suggest that alcohol works with nicotine to further

activate the brain’s reward system and dampen the stress of nicotine exposure.The study

is published in The Journal of Neuroscience.

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